A rare condition that makes hair truly untamable, all thanks to these genes: ScienceAlert

It’s a hair condition that has frustrated parents for decades, scientists now believe they’ve discovered The genes responsible For the treatment of “non-stretchy hair syndrome”. Yes, it is really something.

Unextended hair syndrome is more than just tough hair. As its name suggests, it’s hair that stands out from all angles, making it nearly impossible to tame let alone comb.

It usually begins in children between the ages of three months and 12 years and is characterized by straw blonde or curly silver blonde hair. It is usually wavy, dry and brittle, and thanks to its appearance it is sometimes called spun glass hair, pili trianguli et canaliculi or cheveux incoiffables.

Boris Johnson or Albert Einstein It might come to mind, but while these top guys are notorious for their unruly locks, with very few cases of unbreakable hair syndrome in the world, it’s highly unlikely that they would ever have had or suffer from the condition. Besides, the condition tends to improve or even disappear in adulthood.

Not much research has been done on this rare condition, which first appeared in published articles in the 1970s. Since then, fewer than 70 posts have appeared, most of them are case reports.

One of the most Recent Studies Geneticists at the University of Bonn, Germany, participated in 11 children with uncombed hair. They found that the condition appeared to be explained by mutations in three genes that code for known proteins in hair follicles.

However, since this study was widely reported by the press, more families with children are presenting with the condition, and now the same scientists have repeated the genetics with more than 100 children. They confirmed that in 76 of these children, the cause was linked to mutations in the PADI3 gene as well as the involvement of two other genes, all of which code for important proteins involved in the formation of hair fibres.

Human variation in appearance, including hair, is the result of the many small differences in our genes among the world’s population.

When a gene mutation occurs, it sometimes leads to a change in the protein’s function. If this protein is present in the hair follicles, the hair will likely look different. So it can be brown, blonde, curly, thick, straight, red, or even bald.

There are a few known inherited variations in the shape and strand of hair fibers, but they are rarely associated with any serious disease. Interestingly, the proteins that are most often affected are in the inner root sheath: three layers of hair follicles help set shape in the hair fiber.

recessive genes

We also know that uncombable hair is a “recessive” genetic trait. In other words, both parents must be carriers of the mutated gene, even though they may not carry it themselves. Then, if their child inherits one copy of the affected gene from each parent, they will have the syndrome.

So why study genetic hair disorders? This type of genetic study yields enough information that parents can now order a genetic test that may help allay any concerns about it. Other rare cases It can affect the hair.

From a scientific perspective, it also helps the hair biology research community understand more about normal hair growth and the importance of different proteins for controlling the look and feel of hair. For example, we can now explain why PADI3 changes the shape of hair by learning more about how it works in the follicle.

Poetry is one of the most culturally distinct personality traits. Her style, shape, color and really her absence is something everyone thinks about every day. A huge hair care industry has developed over the last century to help us all manage our hair.

So when a rare condition leads to such a wonderful change but impossible to manage change in hair, it is easy to appreciate why scientists want to understand how this happens and help families with affected children understand it better too.Conversation

Jill WestgateDirector of Business Development, College of Life Sciences, University of Bradford.

This article has been republished from Conversation Under Creative Commons License. Read the original article.

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